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Carisoprodol is a white, crystalline powder, having a mild, characteristic odor and a bitter taste. It is very slightly soluble in water; freely soluble in alcohol, in chloroform, and in acetone; its solubility is practically independent of pH. Carisoprodol is present as a racemic mixture. The molecular formula is C 12 H 24 N 2 O 4 , with a molecular weight of 260.33. The structural formula is.Other ingredients: alginic acid, magnesium stearate, potassium sorbate, starch, tribasic calcium phosphate.Carisoprodol is a centrally acting skeletal muscle relaxant that does not directly relax tense skeletal muscles in man. The mode of action of carisoprodol in relieving acute muscle spasm of local origin has not been clearly identified, but may be related to its sedative properties. In animals, carisoprodol has been shown to produce muscle relaxation by blocking interneuronal activity and depressing transmission of polysynaptic neurons in the spinal cord and in the soma online pharmacy descending reticular formation of the brain [online soma]. The onset of action is rapid and lasts four to six hours.Carisoprodol is metabolized in the liver and is excreted by the kidneys. One of the products of metabolism, meprobamate, is active as an anxiolytic. The degree to which it contributes to the efficacy of carisoprodol is unknown. Carisoprodol is dialyzable by peritoneal and hemodialysis [online soma carisoprodol].The pharmacokinetics of carisoprodol was determined in a small in vivo biostudy of 5 men and 5 women. When the dose was normalized to 350 mg, the mean peak plasma concentration (Cmax) achieved was 2.29 ± 0.68 ug/mL. Women tended to reach peak plasma concentrations earlier than men (1.45 vs. 2.5 hours) and had a faster apparent oral clearance (0.772 vs. 0.38 L/hour/kg). The clinical significance of these findings is unknown and they may in [buy soma online] part be due to the small number of subjects present in the trial.Carisoprodol is metabolized in the [soma online] liver via cytochrome P450 enzyme, CYP2C19. This enzyme exhibits genetic polymorphism. For example, 15-20% of Asian populations may be expected to be poor metabolizers. For Caucasians and Blacks, the prevalence of poor soma online pharmacy metabolizers is 3-5%. Following a single 350 mg dose of carisoprodol, the corresponding normalized peak concentration of meprobamate, which is a metabolite of carisoprodol, was 2.08 ± 0.48 ug/mL. These levels are approximately ¼ of those seen following a single 400 mg dose of buy soma medication meprobamate.The pharmacokinetic profile of carisoprodol in elderly patients has not been evaluated.Concomitant use of carisoprodol and meprobamate is not recommended. Idiosyncratic Reactions –On very rare occasions, the first dose of carisoprodol has been followed by idiosyncratic buy generic soma symptoms appearing [buy soma online] within minutes or hours. Symptomsreported include: extreme weakness, transient quadriplegia, dizziness, ataxia, temporary loss of vision, diplopia, mydriasis, dysarthria, agitation, euphoria, confusion, and disorientation. Symptoms usually buy soma online subside over the course of the next several hours.Supportive and symptomatic therapy, buy generic soma including hospitalization, may be necessary. Allergic Reactions — Occasionally, within the period of the first to fourth dose of carisoprodol allergic reactions have occurred in patients who have had no previous contact with the drug. Skin rash, erythema multiforme, pruritus, eosinophilia, and fixed drug eruption have been reported withbuy carisoprodol with cross reaction to meprobamate. Severe reactions have been buy soma medication manifested by asthmatic episodes, fever, weakness, dizziness, angioneurotic edema, buy soma online smarting eyes, hypotension, and anaphylactoid shock. (See also Idiosyncratic Reactions under “Warnings.” ) In case of allergic or idiosyncratic reactions to online carisoprodol, discontinue the drug and initiate appropriate symptomatic therapy, which may include epinephrine, antihistamines, and in severe cases buy soma online corticosteroids. Usage in Pregnancy and Lactation –The safety of this drug in pregnancy or lactation has not been soma online pharmacy established. Therefore, use of this drug in pregnancy, in nursing mothers, or in women of childbearing potential discount soma requires that the potential benefits of the drug be weighed against the potential hazards to buy generic soma mother and child. Carisoprodol is present in breast milk of lactating mothers at concentrations two to four times that of maternal plasma. This factor should be taken into account when use of the drug is contemplated in soma online pharmacy breast-feeding patients.buy generic soma Usage in Children –The efficacy and safety of carisoprodol in patients under 12 years of age has not been determined.
